Detection of Subclinical Paroxysmal Atrial Fibrillation and Its Correlation with Candidate Genes in Patients with Cryptogenic Ischemic Stroke and TIA-Reference-Cited by-同舟云学术

Detection of Subclinical Paroxysmal Atrial Fibrillation and Its Correlation with Candidate Genes in Patients with Cryptogenic Ischemic Stroke and TIA

Published:2021-08-01 Issue:2 Volume:21 Page:42-53
ISSN:1338-4139
Container-title:Acta Medica Martiniana
language:en
Short-container-title:

Author:

Petrovicova A¹,Kurca E²,Andrasova A³,Bernatova J⁴,Blasko P³,Burjanivova T⁵,Duris T⁴,Grendar M⁶,Hasilla J⁷,Malicherova B⁵,Nosal V²,Obona P³,Patrovic L⁸,Sivak S²,Snopek P⁷,Svetlosak M⁹,Vahala P⁷,Cierny D¹⁰

Affiliation:

1. Clinic of Neurology , Faculty Hospital Nitra , Špitálska 6, 949 01 Nitra, Slovak Republic

2. Clinic of Neurology, Jessenius Faculty of Medicine in Martin , Comenius University in Bratislava, and University Hospital Martin , Kollárova 2, 036 59 Martin, Slovak Republic

3. Cardiocenter Nitra , Špitálska 6, 949 01 Nitra, Slovak Republic

4. Clinic of Internal Medicine, Faculty Hospital Nové Zámky , Slovenská ulica 11 A 940 34, Nové Zámky 1, Slovak Republic

5. Department of Molecular Biology and Genomics, Jessenius Faculty of Medicine in Martin , Comenius University in Bratislava , Malá Hora 4C, 03601 Martin, Slovak Republic

6. Bioinformatic centre, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin , Comenius University in Bratislava , Malá Hora 4C, 036 01 Martin, Slovak Republic

7. Clinic of Cardiology, Faculty Hospital Nitra , Špitálska 6, 949 01 Nitra, Slovak Republic

8. Jessenius diagnostic centre , Špitálska 557, 949 01 Nitra, Slovak Republic

9. Department of Arrhythmias and Cardiac Pacing , National Institute for Cardiovascular Diseases , Pod Krásnou hôrkou 1, 833 48 Bratislava 37, Slovak Republic

10. Department of Clinical Biochemistry, Jessenius Faculty of Medicine in Martin , Comenius University in Bratislava, and University Hospital Martin , Kollárova 2, 036 59 Martin, Slovak Republic

Abstract

Abstract Introduction: Cardioembolic etiology is assumed to be the most frequent cause of cryptogenic strokes. The detection of subclinical paroxysmal atrial fibrillation (AF) is important in the correct choice of preventive treatment. The aim of this prospective study was to detect the incidence of AF in patients with a cryptogenic stroke or transient ischemic attack (TIA) and to evaluate the association between the presence of AF and selected single-nucleotide polymorphisms (SNP). Methods: Patients with a cryptogenic stroke/ TIA (n=100) and a control group (n=15) of volunteers without significant cardiovascular disease were included in the study during the period of 2014 to 2019. To detect AF they underwent 12 months of ECG monitoring using an implanted loop recorder (ILR). Genotyping for SNPs rs10033464, rs2200733, rs225132, and rs2106261 was performed by a high resolution melting analysis. Results: We found AF to be present in 24 (24%) patients with a cryptogenic stroke/TIA, versus no subjects in the control group. The SNPs rs2106261, rs2200733, rs225132, and rs10033464 were not found to be associated with AF in our study (p=0.240; 1.000; 0.887; 0.589). However, a weak trend for a higher frequency of rs2106261 risk allele A homozygotes was observed in the patients with AF compared to the patients without AF (0.416 vs. 0.263, p=0.073). Homozygotes for allele A of rs2106261 were also present in a significantly higher frequency in AF patients compared to the controls (0.416 vs. 0.133, p = 0.012). Conclusion: In our study paroxysmal AF was a probable etiological factor in 24% of patients with cryptogenic ischemic stroke / TIA during the 12 months of monitoring. The homozygous allele A of rs2106261 was identified to be the possible genetic risk factor of AF, but this should be verified in larger cohorts. The study has been registered at www.clinicaltrials.gov, identifier NCT02216370.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology,General Nursing

Link

https://www.sciendo.com/pdf/10.2478/acm-2021-0007

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