Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Abstract

Abstract Ganglioneuromatosis is a rare disorder characterized by hyperplasia of intestinal ganglia including myenteric plexus and enteric nerve fibers. This disorder is generally described in children, but sporadic cases have also been described in adults. Most human cases arise in the colon and rectum. The disorder has also been described in dogs, mostly juveniles, but rarely in mature dogs with the oldest dog reported with this change being 9 years old. We report the first case in an older dog from Croatia. A 13-year old female, mixed-breed dog had a history of diarrhea and weight loss. Ultrasound revealed focally-extensive markedly thickened small intestine. The changed part of the intestine, measuring 7 mm x 20 mm, was removed on laparotomy and delivered for histopathologic examination. Grossly, the intestine showed circumferential expansion of the intestinal wall, which was whitish in color. Microscopic findings included diffuse hyperplasia of the myenteric and submucous plexus. Focally in the affected tissue a subacute ulcer was evident, which was probably not the cause of intestinal signs, as it presented a localized lesion, while ganglioneuromatosis was a diffuse change in the affected tissue. So far, ganglioneuromatosis was reported in young dogs, rarely in adult dogs. Our report shows that ganglioneuromatosis can also be encountered in older dogs. Although the lesion presents a rare finding, it should be listed as a differential diagnosis in dogs where infectious and neoplastic etiology has been ruled out as cause of diarrhea.