A new brain dedicated PET scanner with 4D detector information-Reference-Cited by-同舟云学术

A new brain dedicated PET scanner with 4D detector information

Published:2022-12-01 Issue:1 Volume:18 Page:107-119
ISSN:1896-530X
Container-title:Bio-Algorithms and Med-Systems
language:en
Short-container-title:

Author:

Gonzalez-Montoro Andrea¹,Barbera Julio²,Sanchez David¹,Mondejar Alvaro²,Freire Marta¹,Diaz Karel²,Lucero Alejandro¹,Jimenez-Serrano Santiago¹,Alamo Jorge²,Morera-Ballester Constantino²,Barrio John¹,Cucarella Neus¹,Ilisie Victor¹,Moliner Laura¹,Valladares Celia¹,Gonzalez Antonio J.¹,Prior John³,Benlloch Jose M.⁴

Affiliation:

1. Instituto de Instrumentación para Imagen Molecular (i3M), Centro mixto CSIC – Universitat Politècnica de València , 46022 , Valencia , Spain .

2. Oncovision, S. A. - Jeronimo de Monsoriu , 92, 46012 , Valencia , Spain .

3. Nuclear Medicine and Molecular Imaging Department , Centre Hospitalier Universitaire Vaudois (CHUV) – Lausanne , Switzerland

4. Instituto de Instrumentación para Imagen Molecular (i3M), Centro mixto CSIC – Universitat Politècnica de València , Instituto i3M - UPV, Edificio 8B, 46022 , Valencia , Spain . Phone: +34 963879907 .

Abstract

Abstract In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.

Publisher

Walter de Gruyter GmbH

Subject

Health Informatics,Biochemistry, Genetics and Molecular Biology (miscellaneous),Medicine (miscellaneous),General Computer Science

Link

https://www.sciendo.com/pdf/10.2478/bioal-2022-0083

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