Oral Lichen Planus – Related Connection with HLA-System Antigens

Author:

Popovska Mirjana1,Atanasovska-Stojanovska Aneta1,Todoroska Sashka2,Radojkova-Nikolovska Vera1,Bedhxeti Lindita Zendeli2,Spasovska-Gjorgovska Ana3,Spasovski Spiro4,Ivanovska-Stojanoska Marija2

Affiliation:

1. University Dental Clinical Centre , Departement of periodontology and oral pathology, Faculty of dentistry , “Ss. Cyril and Methodius University” , Skopje , R.N. Macedonia

2. University Dental Clinical Centre , Departement of periodontology and oral pathology , Skopje, R.N. Macedonia

3. PZU „ Ilinden 96 “ Skopje , R.N. Macedonia

4. „Dr. Spasovski “ Skopje , R.N. Macedonia

Abstract

Abstract Aim:To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral lichen planus. Materials and Method: 73 patients with ROLP and EOLP have been tested. Typing of the HLA antigens has been made for locus A and B. The typing of the HLA was conducted with the use of microlymphocyto toxic test by Terasaki. The reading of the findings has been conducted with an inverse microscope. When a reaction has 4 points it is considered to be positive. Results: The most frequently typified antigens in ROLP from locus A are HLA А2 (57.57%) and А3 (33.33)%, and for locus B 21.21%. In EOLP it is А9 (8888%). In locus B a connection has been found with HLA B8 (77.77%). The statistical analysis with the ×2 test has shown that the carriers of HLA A9 display a relative risk (RR) of 3.65 and ×2=20.72. Consequently, there is high static importance for locus A p<0,001. For locus B, In EOLP for HLA B8, RR=6. 7 ×2=37.64 and p<0,001. ROLP has shown association with HLA A3, where RR=2. 31 and ×2 =9.14 and p<0.05. Conclusions: In ROLP A3 antigen and in EOLP A9 and A8 may be considered as carriers with proneness to OLP.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Reference65 articles.

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