Author:
Gregáň Fridrich,Melicherčík Milan,Gregáň Juraj,Remko Milan
Abstract
AbstractTrisodium O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl) diphosphates were synthesized from sodium dimethylamido-O-(2-cyanoethyl) phosphate and O-alkyl-and O-aryl phosphoric acids. While in the previously described method, sodium hydroxide was used for the preparation of O-phenyl diphosphate, in our current work, we present an improved protocol, where sodium methoxide is used to increase the yields of O-alkyl and O-aryl diphosphates. The structures of final compounds were determined by 1H NMR, 31P NMR, and IR spectroscopy. The sodium O-alkyl- and O-aryl diphosphate salts prepared by this method may be used for the study of biological activity of diphosphate analogues.
Publisher
Springer Science and Business Media LLC
Subject
Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry
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