A new phenanthroindolizidine alkaloid from Tylophora indica-Reference-Cited by-同舟云学术

A new phenanthroindolizidine alkaloid from Tylophora indica

Published:2013-01-01 Issue:2 Volume:67 Page:
ISSN:1336-9075
Container-title:Chemical Papers
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Author:

Dhiman Mini,Khanna Amit,Manju Sreedharannair

Abstract

AbstractA new phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), was isolated from the aerial (leaves and stem) parts of Tylophora indica and characterized using different spectral techniques. Gel chromatography and reverse phase preparative HPLC were used for sample purification. The new alkaloid, VI, was screened for anticancer activity against a panel of different cancer cell lines and it showed significant anticancer activity with IC50 value in the range of 0.89–1.40 μM.

Publisher

Springer Science and Business Media LLC

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry

Link

http://www.springerlink.com/index/pdf/10.2478/s11696-012-0265-9

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