Synthesis of new eburnamine-type alkaloid via direct hydroalkoxylation-Reference-Cited by-同舟云学术

Synthesis of new eburnamine-type alkaloid via direct hydroalkoxylation

Published:2014-01-01 Issue:6 Volume:68 Page:
ISSN:1336-9075
Container-title:Chemical Papers
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Author:

Liu Xiong,Yang Dong-Liang,Liu Jia-Jia,Zhou Jing,Zhao Nana

Abstract

AbstractThis study concerns the preparation of a new eburnamine-type alkaloid, methyl (3α,14β,15β,16α)-17,18-didehydro-14,15-dihydroeburnamine-15-methoxy-14-carboxylate (VIII). This alkaloid was prepared from (+)-17,18-dehydroapovincamine (V) using Lewis acid and/or ion exchange resin as catalyst. The hydroalkoxylation reaction of V with methanol was investigated in terms of catalyst, solvent, temperature, and time of reaction. A one-pot method for synthetising this alkaloid was established. The optimal conditions for the reaction are discussed.

Publisher

Springer Science and Business Media LLC

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11696-013-0512-8

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