Author:
Mokrý Milan,Klimeš Jiří,Pechová Jana
Abstract
AbstractThe present paper deals with the evaluation of nimesulide, 2-phenoxy-4-nitroaniline, the main hydrolytic degradation product of nimesulide, of methylparaben and propylparaben, and eventually of 4-hydroxybenzoic acid by HPLC with UV detection at 254 nm in syrup as a pharmaceutical formulation. HPLC analysis was employed on the reversed phase C18 with methanol and 0.01 M dibasic ammonium phosphate (ρ r = 60: 40, pH 4.0). Validation was performed using standards and a pharmaceutical preparation containing the compounds described above.
Publisher
Springer Science and Business Media LLC
Subject
Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry
Reference16 articles.
1. Photochemical stability of nimesulide of and;Kovaříková;Journal Pharmaceutical Biomedical Analysis,2003
2. Development and validation of a reversed - phase liquid chromatographic method for separation and simultaneous determination of COX - inhibitors in pharmaceuticals and its application to biological fluids;Rao;Biomedical Chromatography,2005
3. High - performance thin - layer chromatography for the determination of nimesulide in human plasma and its use in pharmacokinetic studies of;Pandya;Journal Pharmacy and Pharmacology,1997
4. Determination of nimesulide and hydroxynimesulide in human plasma by high performance liquid chromatography;Glachetti;Biomedical Chromatography,1998
5. Mass spectrometric characterization and HPLC determination of the main urinary metabolites of nimesulide in man of and;Carini;Journal Pharmaceutical Biomedical Analysis,1998
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献