COVID-19 and vitamin D– a systematic review

Author:

Jordan Taja1,Siuka Darko2,Rotovnik Nada Kozjek34,Pfeifer Marija3

Affiliation:

1. University Medical Centre Ljubljana, Department for Radiology , Zaloška c. 7, 1000 Ljubljana , Slovenia

2. University Medical Centre Ljubljana, Department for Gastroenterology , Zaloška c. 7, 1000 Ljubljana , Slovenia

3. University of Ljubljana, Faculty of Medicine , Vrazov trg 2, 1000 Ljubljana , Slovenia

4. Institute of Oncology Ljubljana, Department for Clinical Nutrition , Zaloška c. 2, 1000 Ljubljana Slovenia

Abstract

Abstract Introduction The COVID-19 pandemic has strongly affected global healthcare systems. Prior epidemiological studies on different infectious diseases have shown a strong correlation between serum vitamin D levels and the incidence of certain infectious diseases. Vitamin D has an important immunomodulatory effect on innate immunity and exhibits several other mechanisms in the pathogenesis of the cytokine storm, which is one of the main contributing factors to fatality in COVID-19 patients. Methods A keyword search was conducted in the PubMed and Google Scholar research databases. The abstracts and/or full texts of selected papers were further evaluated. Articles that fulfilled the inclusion criteria were included in the systematic review. Results The 28 studies summarized in this review provide observational findings that vitamin D levels are related to the incidence, severity, and mortality rate of COVID-19 infection. The literature does not suggest that COVID-19 could be eliminated with supplementation of vitamin D, but there are implications that vitamin D deficiency might increase the risk for COVID-19 infection and severity of the disease progression. Discussion Current literature and several guidelines support the supplementation of vitamin D as a reasonable strategy for correcting and preventing vitamin D deficiency. The recommended dose for maintaining normal 25(OH)D levels by consensus is 1000 to 2000 IU vitamin D daily for at-risk teens and adults. Conclusion Vitamin D supplementation might play an important role in protecting from acute respiratory infections like the SARS CoV2, and in high-risk individuals with COVID 19 from progressing to critical clinical condition and reducing mortality.

Publisher

Walter de Gruyter GmbH

Subject

Public Health, Environmental and Occupational Health

Reference56 articles.

1. Coronavirus update (Live): 42,271,844 cases and 1,146,211 deaths from COVID-19 virus pandemic - Worldometer. Accessed October 23rd, 2020 at: https://www.worldometers.info/coronavirus/

2. The COVID-19 pandemic, seasons and the vitamin D laboratory strategy. Accessed Jan 26th, 2022 at: https://www.researchgate.net/publication/350276683_The_COVID-19_Pandemic_Seasons_and_the_Vitamin_D_Laboratory_Strategy

3. Fares A. Factors influencing the seasonal patterns of infectious diseases. Int J Prev Med. 2013;4(2):128-32.

4. Aranow C. Vitamin D and the immune system. J Investig Med. 2011;59(6):881-6. doi: 10.2310/JIM.0b013e31821b8755.

5. Mok CK, Ng YL, Ahidjo BA, Hua Lee RC, Choy Loe MW, Liu J, et al. Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis. BioRxiv. 2020. doi: 10.1101/2020.06.21.162396.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3