In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Author:

Ababsa Zine El Abidine12,Derouiche Mohamed Tahar3,Medjroubi Kamel2,Akkal Salah2

Affiliation:

1. Department of Sciences of Matter, Faculty of Natural Sciences and Life , Larbi BEN M’HIDI University , Oum El Bouaghi - Algeria

2. Unit for the Valorization of Natural Resources, Bioactive Molecules and Physico-Chemical and Biological Analyzes, Faculty of Exact Sciences, Department of Chemistry , Mentouri University of Constantine 1 - Algeria

3. Faculty of Medicine, Department of Pharmacy , University Salah BOUBNIDER of Constantine 03 . Algeria .

Abstract

Abstract Tetraclinis articulata (Thuya of Barbary), endemic to North Africa, is used as a traditional medicine for the treatment of many diseases [1]. We investigated the antidiarrhoel properties of the butanol extract of Tetraclinis articulata (BETA) in male and female Swiss albino mice to support its traditional use. The antidiarrhoeal activity of the plant extract was evaluated in a model of castor oil-induced diarrhoea model in mice and compared to loperamide (a reference inhibitor of diarrhoea). The effect of (BETA) on gastrointestinal motility was determined by the oral administration of charcoal and Castrol oil-induced intestinal fluid accumulation (enteropooling).The (BETA) showed remarkable antidiarrhoeal activity significantly inhibited gastrointestinal motility and castor oil induced enteropolysis (68,18%), more than to the inhibition achieved in loperamide treated mice (60,16%). The second aim of the present study was to evaluate the anti-ulcerative activity of The (BETA), it produced percent protection of control colitis by 77, 40%, while the standard drug (aspirin) produced 81,39% protection. We conclude that Tetraclinis articulata extracts are potential sources of new anti-ulcer agents and antidiarrhoeal drugs.

Publisher

Walter de Gruyter GmbH

Reference10 articles.

1. [1] Benabid, A., “Etude écologique, phytosociologique et sylvopastorale de la Tetraclinaie de l’Amsittene”, Thèse de doctorat, université d’Aix– Marseille III, 1976, 3-4.

2. [2] Bellakhdar, J.; Honda, W., MikiHerb–Drugs and Herbalists in the Maghrib, Institute of the Study of Languages and Cultures of Asia and Africa, Toky, 1982, 13.

3. [3] Bellakhdar, J.; Claisse, R.; Fleurentin, J.; Yaunos, C., Repertory of standard herbal drugs in the Moroccan pharmacopoeia,1991, 35,123-143.

4. [4] Bourkhiss, M.; Ouhssine, M.; Hnach, A.; Amechrouq, A.; Chaouch, B., MarocPhys. Chem. News, 2007, 35, 128–132.

5. [5] Bourkhiss, M.; Ouhssine, M.; Hnach, A.; Satrani, B.; Farah, A., Bull. Soc. Pharm. Bord, 2007, 146, 75–84.

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