Early Correction of Post-Kidney Transplant Hyperglycaemia is Associated with Reduction of the Prevalence of Post-Transplant Diabetes Mellitus
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Published:2021-04-01
Issue:2
Volume:75
Page:99-105
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ISSN:1407-009X
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Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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language:en
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Short-container-title:
Author:
Suhecka Klinta12, Lejnieks Aivars12, Jušinskis Jānis13, Maļcevs Aleksandrs13, Suhorukovs Vadims13, Amerika-Ļebedjkova Diāna3, Straupmane Dagnija3, Pētersons Aivars13, Ziediņa Ieva13
Affiliation:
1. Rīga Stradiņš University , 16 Dzirciema Str., Rīga, LV-1007 , Latvia 2. Rīga East University Hospital , 2 Hipokrāta Str., Rīga, LV-1038 , Latvia 3. Pauls Stradiņš Clinical University Hospital , 13 Pilsoņu Str., Rīga, LV-1002 , Latvia
Abstract
Abstract
Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus (PTDM) and its associated complications. In a single centre, the prospective study included adult kidney transplant recipients without diabetes mellitus whose pre-transplant glucometabolic data did not show signs of diabetes mellitus. Starting from the first day after kidney transplantation, patients were closely monitored for hyperglycaemia; glucose level measurements were started to obtain pre-prandial levels. If the blood glucose level exceeded 11.1 mmol/l, hyperglycaemia was corrected with short-acting insulin. A total of 14 patients completed a three-month follow-up. During the first post-transplant week, the blood glucose level exceeded 11.1 mmol/l in nine patients (63.9%). From those patients five (55.5%) did not develop PTDM. None of the patients who did not need insulin treatment developed PTDM. Higher pre-lunch glucose levels increased the risk of developing PTDM (p = 0.006). Patients with diabetes required a two times higher insulin dosage than other patients during the first post-transplantation week. We found that hyperglycaemia is a common problem in the early post-transplant period. Early recognition and correction of inpatient hyperglycaemia was associated with reduction of the prevalence of PTDM in more than a half of the patients in the studied group at three months post transplant.
Publisher
Walter de Gruyter GmbH
Subject
Multidisciplinary
Reference19 articles.
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