New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties-Reference-Cited by-同舟云学术

New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties

Published:2023-02-01 Issue:1 Volume:77 Page:66-72
ISSN:2255-890X
Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
language:en
Short-container-title:

Author:

Gaziev Afig Gurbanali¹,Shamilov Elshan Nuraddin²,Abdullayev Asim Sabri²,Abdullaeva Gulsum Miribad¹,Mahmudova Nargiz Shaiq¹,Sadigova Gunel Aliheydar¹,Melnikova Natalia Y.³,Babayeva Aytan Zulfi³

Affiliation:

1. 1 Institute of Physiology named after academician Abdulla Garayev, National Academy of Sciences of Azerbaijan , 22 Sharifzadeh Str., Baku, AZ1100 , Azerbaijan

2. 2 Institute of Radiation Problems, National Academy of Sciences of Azerbaijan , 9 B. Vahabzadeh, Baku, AZ1143 , Azerbaijan

3. 3 Institute of Catalysis and Inorganic Chemistry named after academician M. F. Nagiyev, National Academy of Sciences of Azerbaijan , 113 H. Javid Ave., Baku, AZ1143 , Azerbaijan

Abstract

Abstract The article is devoted to the study of the biological properties of nanocomposites obtained by immobilisation of precious metals (Au2+, Ag2+) in the structures of extracts of plant hepatoprotectors (milk thistle, saffron), in experiments on small sexually mature laboratory animals. Aqueous solutions of nanocomposites were administered to animals intraperitoneally 30 minutes prior to exposure to ionising radiation. Quantitative changes in lipid peroxidation were determined on the basis of the analysis of the concentration of malonic dealdehyde and hydroperoxide in liver tissue of control and experimental animals. It was revealed that nanocomposites introduced to animals before irradiation partially protect them from its destructive effect. More pronounced hepatoprotective effects in comparison with Ag2+ ions are manifested by Au2+ ions. Animals were also tested for behavioural responses in an open field model against the background of the introduction of a corresponding dose of the nanocomposite solution before irradiation. There were also changes in behavioural responses.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/prolas-2023-0009

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