Risk Factor Analysis for Gout in the Latvian Population
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Published:2020-02-01
Issue:1
Volume:74
Page:7-11
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ISSN:2255-890X
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Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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language:en
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Short-container-title:
Author:
Nagle Erika1, Luksa Nellija2, Moisejevs Georgijs23, Gailīte Linda2
Affiliation:
1. Department of Biology and Microbiology , Rīga Stradiņš University , 16 Dzirciema Str., Rīga , LV- 1007 , Latvia 2. Scientific Laboratory of Molecular Genetics , Rīga Stradiņš University , 16 Dzirciema Str., Rīga , LV- 1007 , Latvia 3. Department of Nephrology and Renal Replacement Therapy , Rīga East Clinical University Hospital , 2 Hipokrāta Str., Rīga , Latvia , LV- 1038
Abstract
Abstract
Gout (Gr. podagra) is a multifactorial pathology, which means that both genetic and environmental factors play a role in the aetiology of the disease. For these reasons, revealing risk factors could be of very high importance in prevention and treatment of gout. In the present study, we found that a major role in gout predisposition is played by specific alleles in the ABCG2 gene. The study used survey data for 43 gout patients and 99 healthy control individuals who were geno-typed for rs2231142. It was found that allelic variant rs2231142 in the ABCG2 gene had the strongest association with gout. Among other co-factors studied, sex, and increased body mass index were associated with gout.
Publisher
Walter de Gruyter GmbH
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