Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?-Reference-Cited by-同舟云学术

Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?

Published:2022-12-01 Issue:5-6 Volume:76 Page:569-577
ISSN:2255-890X
Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
language:en
Short-container-title:

Author:

Rodina Jekaterina¹²,Derovs Aleksejs¹²³⁴⁵

Affiliation:

1. Rīga East University Hospital , 2 Hipokrāta Str., Rīga, LV-1038 , Latvia

2. Department of Internal Diseases , Rīga Stradiņš University , 16 Dzirciema Str., Rīga, LV-1007 , Latvia

3. Department of Infectology , Rīga Stradiņš University , 16 Dzirciema Str., Rīga, LV-1007 , Latvia

4. JSC Veselības centru apvienība , 16 Saharova Str., Rīga, LV-1021 , Latvia

5. Latvian Maritime Medicine Centre , 27 Patversmes Str., Rīga, LV-1005 , Latvia

Abstract

Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier to allergens, pathogens, and toxins. Leaky gut syndrome is defined as a gut mucosal barrier dysfunction, which results in abnormally increased intestinal permeability. Research shows that leaky gut syndrome (LGS) has a pathogenetic relationship with a series of gastrointestinal and extra-intestinal disorders. This review discusses the current understanding of intestinal barrier composition and pathological contribution of LGS to various diseases. The major aim of this paper is to review different methods for diagnostics and evaluation of intestinal wall permeability, identifying their priorities and disadvantages.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/prolas-2022-0089

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