A New Perspective of Genome Regulation from the Physics of Life Standpoint
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Published:2022-04-01
Issue:2
Volume:76
Page:163-167
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ISSN:2255-890X
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Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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language:en
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Short-container-title:
Author:
Ērenpreisa Jekaterina1, Giuliani Alessandro2
Affiliation:
1. Latvian Biomedical Research and Study Centre , 1-1k Rātsupītes Str ., Rīga , , Latvia 2. Istituto Superiore di Sanità , Viale Regina Elena 299 , , Roma , Italy
Abstract
Abstract
The convergence between a statistical mechanics and biological approach in elucidating some basic features of cell differentiation opens new avenues of research in gene expression regulation and holds some promises in terms of a re-differentiation approach to a cancer cure. The message emerging from two recent papers by the authors of the present communication follows very simple basic lines. The time-honored concept of homeostasis, at the very basis of physiology, is in action even at the microscopic level of gene expression regulation, where a continuous (relatively small) oscillation of gene expression is mandatory for keeping alive the substantial stability of the gene expression profile typical of a given cell type. This mechanism of stability, when oscillation exceeds a certain threshold, is responsible for the spreading of a large-scale perturbation invading the entire genome and eventually giving rise to cell fate change. The material basis of this model was discovered in the onset of a global reorganisation of chromatin driven by fusion-splitting dynamics of pericentromeric associated domains that, by selective folding/unfolding of chromatin, allows for a global scale re-arrangement of genome expression.
Publisher
Walter de Gruyter GmbH
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