Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests
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Published:2023-02-01
Issue:1
Volume:77
Page:49-52
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ISSN:2255-890X
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Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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language:en
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Short-container-title:
Author:
Ļeonova Elīna1, Dišlere Kristīne2, Rostoka Evita1, Baumane Larisa3, Bisenieks Egils3, Duburs Gunārs3, Sjakste Nikolajs12
Affiliation:
1. 1 Faculty of Medicine , University of Latvia , 1 Jelgavas Str., Rīga, LV-1004 , Latvia 2. 2 Institute of Biology of the University of Latvia , 1 Jelgavas Str., Rīga, LV-1004 , Latvia 3. 3 Latvian Institute of Organic Synthesis , 26 Aizkraukles Str., Rīga, LV-1006 , Latvia
Abstract
Abstract
The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.
Publisher
Walter de Gruyter GmbH
Reference12 articles.
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Cited by
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