Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia
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Published:2019-07-12
Issue:4
Volume:73
Page:312-316
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ISSN:1407-009X
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Container-title:Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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language:en
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Short-container-title:
Author:
Laizāne Gunta12, Ķīvīte Anda3, Grope Ilze1, Smane Liene12, Miklaševics Edvīns45, Ozoliņa Laura4, Gardovska Dace12
Affiliation:
1. Department of Paediatrics , Rīga Stradiņš University , 45 Vienības Av., Rīga , LV- 1004 , Latvia 2. Children’s Clinical University Hospital , 45 Vienības Av., Rīga , LV- 1004 , Latvia 3. Department of Public Health and Epidemiology , Rīga Stradiņš University , 9 Kronvalda Blvd., Rīga , LV- 1010 , Latvia 4. Department of Biology and Microbiology , Rīga Stradiņš University , 16 Dzirciema Str., Rīga , LV- 1007 , Latvia 5. Institute of Oncology , Pauls Stradiņš Clinical University Hospital , 13 Pilsoņu Str., Rīga , LV- 1002 , Latvia
Abstract
Abstract
In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.
Publisher
Walter de Gruyter GmbH
Subject
Multidisciplinary
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2 articles.
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