Effect of Beta-Alanine Supplementation on Exercise-Induced Cell Damage and Lactate Accumulation in Female Basketball Players: a Randomized, Double-Blind Study

Abstract

Beta-alanine (BA) is a supplement that has received attention for its buffering potential among athletes. The aim of this study was to investigate the effects of BA supplementation on exercise performance and exercise-induced cell damage in female basketball players. Twenty-two female basketball players participated in a randomized, double-blind study. They ingested 6.4 g·day^-1 of BA or an isocaloric placebo (dextrose) over 4 weeks. Exercise performance including aerobic (Bruce test), anaerobic (Wingate test), intermittent (Yo-Yo test) and basketball performance (countermovement jump and free throw shots) was measured before and following the intervention. Exercise measures were performed at the lab and free throw shots were undertaken on a wooden indoor basketball court. Blood samples were also collected before and after the exhaustive exercise to assess lactate concentration, creatine kinase (CK), lactate dehydrogenase (LDH) and malondialdehyde (MDA) activity. The exhaustive exercise test induced an increase in lactate concentration and MDA, CK and LDH activity (all p < 0.05). BA supplementation significantly reduced the lactate response to exhaustive exercise (p = 0.001); however, it had no significant effect on exercise-induced MDA, CK and LDH activity (all p > 0.05). Furthermore, exercise performance measures improved from pre- to post-test regardless of supplement/placebo ingestion (all p < 0.05). BA consumption over 4 weeks significantly reduced lactate accumulation following exhaustive exercise, but had no ergogenic effect in female basketball players. Usual dosing of BA does not seem to exhibit protective effect against oxidative damage.