Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product-Reference-Cited by-同舟云学术

Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Published:2020-04-01 Issue:1 Volume:13 Page:98-101
ISSN:1337-978X
Container-title:Acta Chimica Slovaca
language:en
Short-container-title:

Author:

Milata Viktor¹,Holúbková Eva¹

Affiliation:

1. Department of Organic Chemistry , Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology , Slovak University of Technology , 812 37 Bratislava, Radlinského 9 , Slovakia

Abstract

Abstract Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/acs-2020-0014

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