1. 1 Pharmacology Toxicology Laboratory, Faculty of Nature and Life Sciences , University of Brothers Mentouri , Constantine , Algeria .
2. 2 Laboratory of Cellular and Molecular Biology, Faculty of Nature and Life Sciences , University of Brothers Mentouri , Constantine , Algeria .
3. 3 Department of Biochemistry and Biological Cellular and Molecular, Faculty of Nature and Life Sciences , University of Brothers Mentouri , Constantine , Algeria .