Mammalian hibernation: a unique model for medical research-Reference-Cited by-同舟云学术

Mammalian hibernation: a unique model for medical research

Published:2021-12-01 Issue:2 Volume:1 Page:65-68
ISSN:2719-8073
Container-title:Frigid Zone Medicine
language:en
Short-container-title:

Author:

Xing Xin¹,Wang Shiqiang²³

Affiliation:

1. College of Life Science , Shenyang Normal University , Shenyang , China

2. State Key Laboratory of Membrane Biology , College of Life Science , Peking University , Beijing , China

3. Chinese Institute for Brain Research , Beijing , China

Abstract

Abstract Hibernation is an adaptive behavior for some small animals to survive cold winter. Hibernating mammals usually down-regulate their body temperature from ~37°C to only a few degrees. During the evolution, mammalian hibernators have inherited unique strategies to survive extreme conditions that may lead to disease or death in humans and other non-hibernators. Hibernating mammals can not only tolerant deep hypothermia, hypoxia and anoxia, but also protect them against osteoporosis, muscle atrophy, heart arrhythmia and ischemia-reperfusion injury. Finding the molecular and regulatory mechanisms underlying these adaptations will provide novel ideas for treating related human diseases.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/fzm-2021-0008

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