2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg<sup>2+</sup> Ion and its Docking Studies in Cancer Treatment-Reference-Cited by-同舟云学术

2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg²⁺ Ion and its Docking Studies in Cancer Treatment

Published:2022-12-01 Issue:1-2 Volume:27 Page:25-33
ISSN:2084-4506
Container-title:Chemistry-Didactics-Ecology-Metrology
language:en
Short-container-title:

Author:

Ziarani Ghodsi Mohammadi¹^ORCID,Ashtiani Shadi Tahmasebi¹^ORCID,Mohajer Fatemeh¹^ORCID,Badiei Alireza²^ORCID,Gaikwad Sunil V.³^ORCID,Varma Rajender S.⁴^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Physics and Chemistry , Alzahra University , Tehran , Iran ; P.O. Box: 1993893973, phone/fax +98 2186613937

2. School of Chemistry, College of Science , University of Tehran , Tehran , Iran

3. Department of Chemistry, Dr. D. Y. Patil ACS Women’s College Pimpri Pune-411018; Affiliation to Savitribai Phule Pune University, Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava , Ilkovicova 6, 842 15 Bratislava , Slovakia

4. Regional Center of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute , Palacky University in Olomouc , Slechtitelu, Olomouc , Czech Republic

Abstract

Abstract The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO3H and its application was explored as a highly selective fluorescent sensor for Hg2+ ion; fluorescence intensity was decreased selectively by Hg2+ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg2+ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.

Publisher

Walter de Gruyter GmbH

Subject

Ecology,Education,Environmental Chemistry,Environmental Engineering

Link

https://www.sciendo.com/pdf/10.2478/cdem-2022-0004

Reference38 articles.

1. [1] Li X, Tu Y, Tang L, Gao Q, Alonso PL. The role of research in China’s successful elimination of malaria. Nat Med. 2022;28:1336-8. DOI: 10.1038/s41591-022-01824-0.10.1038/s41591-022-01824-035641827

2. [2] Mhaske SB, Argade NP. The chemistry of recently isolated naturally occurring quinazolinone alkaloids. Tetrahedron. 2006;62:9787-826. DOI: 10.1016/j.tet.2006.07.098.10.1016/j.tet.2006.07.098

3. [3] Wang Y, Gao H, Gong C, Rizvi SFA, Liu X, Shi X, et al. N-quaternization of heterocyclic compound extended the emission to NIR with large Stokes shift and its application in constructing fluorescent probe. Spectrochim Acta, Part A. 2022;267:120566. DOI: 10.1016/j.saa.2021.120566.10.1016/j.saa.2021.12056634799226

4. [4] Auti PS, George G, Paul AT. Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids. RSC Adv. 2020;10:41353-92. DOI: 10.1039/D0RA06642G.10.1039/D0RA06642G905792135516563

5. [5] Hour MJ, Huang LJ, Kuo SC, Xia Y, Bastow K, Nakanishi Y, et al. 6-alkylamino-and 2, 3-dihydro-3’-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem. 2000;43:4479-87. DOI: 10.1021/jm000151c.10.1021/jm000151c11087572

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A quinazolinone based optical probe for the simultaneous determination of Fe3+and Cu2+ content in aqueous samples; An experimental and theoretical investigations;Journal of Molecular Structure;2024-12

2. Facile Green Synthesis of Cinnamomum tamala Extract Capped Silver Nanoparticles and its Biological Applications;Ecological Chemistry and Engineering S;2023-03-01