Author:
Shaikh Anwar,Giridhar Rajani,Megraud Francis,Yadav Mange
Abstract
Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes againstHelicobacter pyloriNovel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential againstHelicobacter pyloriand other microorganisms was investigated. These compounds were found to possess strong activity againstHelicobacter pyloriwith a minimum inhibitory concentration of 0.5 mg L-1. They also exhibited moderate activity againstEscherichia coli, Staphylococcus aureus, Bacillus pumilusandStaphylococcus epidermidis.These bismuth-fluoroquinolone complexes have the potential to be developed as drugs againstH. pylorirelated ailments.
Subject
Pharmaceutical Science,Pharmacology,General Medicine
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