Ketoprofen Lysine Salt Has No Gastroprotective Effect in Comparison with Ketoprofen in Female Rats After Ethyl Alcohol Intoxication-Reference-Cited by-同舟云学术

Ketoprofen Lysine Salt Has No Gastroprotective Effect in Comparison with Ketoprofen in Female Rats After Ethyl Alcohol Intoxication

Published:2023-09-01 Issue:3 Volume:84 Page:69-79
ISSN:2084-0535
Container-title:Polish Hyperbaric Research
language:en
Short-container-title:

Author:

Ruszel Kinga¹,Nieradko-Iwanicka Barbara²,Naja-Wiśniewska Magdalena³,Wójtowicz Paulina⁴

Affiliation:

1. Doctoral School , Medical University of Lublin , Chodzki 7 Street , Lublin , Poland

2. Hygiene and Epidemiology Department , Medical University of Lublin , Poland

3. Department of Geriatrics , Stefan Cardinal Wyszyński Provincial Specialist Hospital in Lublin , Poland

4. Department of Internal Diseases, Endocrinology and Diabetology , Provincial Specialist Hospital. Stefan Cardinal Wyszyński , Lublin

Abstract

Abstract Ketoprofen lysine salt - a new non steroidal antiinflammatory drug (NSAID) is an improved formulation of ketoprofen. The former is believed to have gastroprotective properties, the latter to kill acute pain and increase the risk of gastric mucosa damage. In East Europe binge drinking and taking NSAIDs on the day after is common. The aim of the study was to verify the hypothesis about the gastroprotective effect of ketoprofen lysine salt after exposure to 50% alcohol. The experiment was carried out on 36 female Wistar rats divided into 6 groups of 6: 1. 50% ethanol 2. 0.9% NaCl 3. 0.9% NaCl and ketoprofen 4. 50% ethanol and ketoprofen 5. 0.9% NaCl and ketoprofen lysine salt 6. 50% ethanol and ketoprofen lysine salt On day 7 animals were sacrificed. Their stomachs were dissected for histopathological examination. Microscopic examination of stomachs from groups 1, 3,4,5,6 revealed non-specific, high-grade lymphocytic-plasmocytic inflammation of the gastric mucosa. Conclusions - Ketoprofen lysine salt and ketoprofen damage gastric mucosa in female rats after and without alcohol intoxication. Ketoprofen lysine salt has no gastroprotective effect

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/phr-2023-0018

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