Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes-Reference-Cited by-同舟云学术

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Published:2020-09-01 Issue:3 Volume:33 Page:125-131
ISSN:2300-6676
Container-title:Current Issues in Pharmacy and Medical Sciences
language:en
Short-container-title:

Author:

Harasym Nataliya¹^ORCID,Mandzynets Svitlana¹^ORCID,Sanahursky Dmytro¹^ORCID

Affiliation:

1. Ivan Franko National University of Lviv , Ukraine

Abstract

Abstract We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.

Publisher

Walter de Gruyter GmbH

Subject

Pharmacology,Molecular Biology,General Medicine,Biochemistry

Link

https://www.sciendo.com/pdf/10.2478/cipms-2020-0023

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