Successful treatment of a patient with rheumatoid arthritis and comorbid multicentric reticulohistiocytosis

Author:

Chang Fei12,Wu Chanyuan3456,Wang Tao7,Wang Qian3456

Affiliation:

1. Trainee Doctor at Peking Union Medical College Hospital , Beijing , China

2. Department of Rheumatology and Clinical Immunology , Second Hospital of Hebei Medical University , Shijiazhuang , Hebei , China

3. Department of Rheumatology and Clinical Immunology , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China

4. National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID) , Ministry of Science & Technology , Beijing , China

5. State Key Laboratory of Complex Severe and Rare Diseases , Peking Union Medical College Hospital (PUMCH) , Beijing , China

6. Key Laboratory of Rheumatology and Clinical Immunology , Ministry of Education , Beijing , China

7. Department of Dermatology , State Key Laboratory of Complex Severe and Rare Diseases , Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases , Beijing , China

Abstract

Abstract Multicentric reticulohistiocytosis (MRH) is a rare disease of unknown pathogenesis, characterized by skin histiocytosis and destructive arthritis. The present study describes a 53-year-old woman who presented with rheumatoid arthritis (RA) and MRH, which is a clinically rare entity. Diagnosis of MRH was based on nodule pathology. Meanwhile, the patient had typical arthritis, was positive for serum anti-cyclic citrullinated peptide (anti-CCP) antibodies and synovitis confirmed by joint ultrasound, and was diagnosed with RA. Her symptoms resolved with glucocorticoids and methotrexate.

Publisher

Walter de Gruyter GmbH

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