The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue-Reference-Cited by-同舟云学术

The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

Published:2014-01-01 Issue:2 Volume:19 Page:
ISSN:1689-1392
Container-title:Cellular and Molecular Biology Letters
language:
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Author:

Potkin Vladimir,Shcharbin Dzmitry,Denisov Andrey,Paschkevich Svetlana,Bryszewska Maria,Petkevich Sergey,Kletskov Alexey,Lapotko Dmitri,Kazbanov Vladimir,Gurinovich Tatiana,Kulchitsky Vladimir

Abstract

AbstractWe used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

Publisher

Walter de Gruyter GmbH

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://link.springer.com/content/pdf/10.2478/s11658-014-0193-5.pdf

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