Author:
Hirokawa Yoshifumi,Takagi Akimitsu,Uchida Katsunori,Kozuka Yuji,Yoneda Misao,Watanabe Masatoshi,Shiraishi Taizo
Abstract
AbstractIn this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference13 articles.
1. a transforming growth factor - beta - induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer;Brunschwig;Cancer Res,2003
2. Cadherin expression in human prostate carcinoma cell lines An epithelial - mesenchymal transformation mediating adhesion with stromal cells;Tran;Am J Pathol,1999
3. Nonapical and cytoplasmic expression of interleukin - and correlates with cell proliferation and microvessel density in prostate cancer http dx doi org;Murphy;Clin Cancer Res,2005
4. Characterization of TGF - beta - regulated interleukin - expression in human prostate cancer cells http dx doi org;Lu;Prostate,2006
5. Distinct CXC chemokines mediate tumorigenicity of prostate cancer cells;Moore;Am J Pathol,1999
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献