Author:
Nowak Paweł,Saluk-Juszczak Joanna,Olas Beata,Kołodziejczyk Joanna,Wachowicz Barbara
Abstract
AbstractMany selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors or drugs. The effects of a new selenocompound — bis(2-aminophenyl)-diselenide on oxidative/nitrative changes in human plasma proteins induced by peroxynitrite (ONOO−) were studied in vitro and compared with the those of ebselen, a well-known antioxidant. We also studied the role of the tested selenocompounds in peroxynitrite-induced plasma lipid peroxidation. Exposure of the plasma to peroxynitrite (0.1 mM) resulted in an increase in the level of carbonyl groups and nitrotyrosine residues in plasma proteins (estimated using the ELISA method and Western blot analysis). In the presence of different concentrations (0.025–0.1 mM) of the tested selenocompounds, 0.1 mM peroxynitrite caused a distinct decrease in the level of carbonyl group formation and tyrosine nitration in plasma proteins. Moreover, these selenocompounds also inhibited plasma lipid peroxidation induced by ONOO−1 (0.1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Design, one-pot synthesis, cytotoxic, in vivo anticancer, antioxidant and antimicrobial evaluation of a novel mixed schiff base ligand and its metal complexes;Results in Chemistry;2022-01
2. Anticancer, in vitro cytotoxicity and antimicrobial properties of a Schiff base ligand, 3-((2-(-(1-(2-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-(p-tolyl)butanamide, and its metal complexes;Journal of Coordination Chemistry;2021-08-18
3. Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics;Molecules;2021-07-23
4. Synthesis, anticancer and larvicidal activities of a novel Schiff base ligand, 3-((2-((1-(4-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-(p-tolyl)butanamide and its Mn(II), Fe(III), Co(II), Ni(II) and Zn(II) complexes;Results in Chemistry;2021-01
5. Synthesis, cytotoxic, anticancer and antimicrobial activities of some metal complexes of a novel tetradentate Schiff base ligand, (E)-3-((2-((E)-(1-(2-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-phenylbutanamide;Results in Chemistry;2021-01