Kikuchi-Fujimoto disease and systemic lupus erythematosus – an enigmatic association for clinicians and pathologists: Case report and short literature review

Author:

Tarabichi Shirley12ORCID,Nicola Andreea Alexandra13,Radu Lucia12,Enache Simona3,Busuioc Constantin Ioan3,Moldovianu Ana-Maria4,Nitu Andra-Florina5,Predeteanu Denisa13,Sarafoleanu Codrut12ORCID

Affiliation:

1. “Carol Davila” University of Medicine and Pharmacy , Bucharest , Romania

2. ENT&HNS Department , “Sfanta Maria” Hospital , Bucharest , Romania

3. Internal Medicine and Rheumatology Department , “Sfanta Maria” Clinical Hospital , Bucharest , Romania

4. Hematology and Stem Cell Transplantation Department , Fundeni Clinical Institute , Bucharest , Romania

5. Radiology and Imaging Department , “Sfanta Maria” Hospital , Bucharest , Romania

Abstract

Abstract Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign condition of the lymphatic tissue whose cause has not been fully elucidated. Although it has been thought that various viral infections are involved in the onset of the disease, its immunological characteristics expressed by the proliferation of cytotoxic CD8-positive T lymphocytes and histiocytic phagocytosis place it at the border of autoimmunity. Sharing immunological mechanisms, clinical manifestations, and epidemiological data (both are described in young women) with systemic lupus erythematosus (SLE), the association of the two pathologies represents a challenge for both clinicians and pathologists. We present the case of a young woman with SLE with immunological, haematological and articular involvement, who associates a few months after diagnosis the significant swelling of the submandibular glands and latero-cervical lymphadenopathy. Histopathological and immunohistochemical examinations subsequently certify the diagnosis of histiocytic necrotizing lymphadenitis associated with the autoimmune disease.

Publisher

Walter de Gruyter GmbH

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference25 articles.

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2. 2. Masab M, Surmachevska N. Kikuchi Disease. [Internet]. Stat-Pearls. Available from: https://www.statpearls.com/nursepractitioner/ce/activity/34571. Last reviewed: 29 June 2021.

3. 3. Gaman M, Vladareanu AM, Dobrea C, Onisai M, Marinescu C, Voican I, et al. A challenging case of Kikuchi-Fujimoto disease associated with systemic lupus erythematosus and review of the literature. Case Rep Hematol. 2018;2018:1791627. DOI: 10.1155/2018/1791627.10.1155/2018/1791627

4. 4. Pepe F, Disma S, Teodoro C, Pepe P, Magro G. Kikuchi-Fujimoto disease: a clinicopathologic update. Pathologica. 2016;108(3):120-9.

5. 5. Richards M. Kikuchi disease. [Internet]. UpToDate. Available from: https://www.uptodate.com/contents/kikuchi-disease. Last updated: September 29, 2021.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Kikuchi-Fujimoto disease: A comprehensive review;World Journal of Clinical Cases;2023-06-06

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