Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013

Author:

Andersen Hartvig Rune1,Bjerre Holm Niels1,Weihe Dalsgaard Petur1,Ask Reitzel Lotte1,Breum Müller Irene1,Linnet Kristian1

Affiliation:

1. Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences University of Copenhagen, Frederik V’s Vej 11, 2100 Copenhagen, Denmark

Abstract

Abstract We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.

Publisher

Walter de Gruyter GmbH

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