Glucocorticoids in Leprosy Reversal reaction

Author:

Yuniati Renni1,Khrisna Matthew Brian1

Affiliation:

1. Department of Dermatology and Venereology , Diponegoro University , Semarang , Indonesia

Abstract

Abstract Leprosy is a disease that is caused by Mycobacterium leprae which results in lots of disabilities in the patients. Leprosy is treated by multi-drug therapy regimen; however, this therapy might cause leprosy reactions in the patients. There are several types of lepromatous reaction: type 1 reaction, type 2 reaction and neuritis. Type 1 reaction mainly occurs in BB, BL and BT forms of leprosy and is characterized by exacerbation of preexisting lesions. The therapy of this reaction according to the WHO guideline is corticosteroid therapy. This article will explain several key points related to the corticosteroid therapy in leprosy reversal reactions, including the side effects and alternative therapies available.

Publisher

Walter de Gruyter GmbH

Subject

Dermatology

Reference30 articles.

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3. 3. Nery JA da C, Bernardes Filho F, Quintanilha J, Machado AM, Oliveira S de S, Sales AM. Understanding the type 1 reactional state for early diagnosis and treatment: a way to avoid disability in leprosy. An Bras Dermatol. 2013;88(5):787-92.

4. 4. Scollard DM, Smith T, Bhoopat L, Theetranont C, Rangdaeng S, Morens DM. Epidemiologic characteristics of leprosy reactions [Internet]. Int J Lepr Other Mycobact Dis. 1994 [cited 2018 Dec 11];62(4):559-67. Available from: http://ila.ilsl.br/pdfs/v62n4a09.pdf

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