Drosophila melanogaster research: history, breakthrough and perspectives

Abstract

Abstract The common fruit fly, or Drosophila Melanogaster, has been used as an object of biomedicals studies for over a century. It has been mostly employed in genetic research, as it exhibits several advantages which make its use relatively easy and cheap, with the results widely translatable into further vertebrate studies. This model been the basis of the work of Christiane Nusslein-Volhard, who together with Eric Wieschaus unravelled much of the mystery surrounding early drosophila development in the 1970s-1980s, laying foundations for broader understanding of multicellular organism embryogenesis, which brought them a Nobel prize in Physiology and Medicine in 1995. The knowledge gained from drosophila studies improves the basic understanding of developmental processes, while the model itself is relatively easy to maintain, analyse and translate the results onto other species. While models such as Zebrafish present better with other vertebrates, drosophila remains a very important element of genetic research, finding even more applications with the development of current science and medicine. Hence, in this short review, the outline of the history, breakthroughs and perspectives of the drosophila research has been presented.