Early Acute Graft Rejection in a Heart Transplanted Child with Dilated Cardiomyopathy-Reference-Cited by-同舟云学术

Early Acute Graft Rejection in a Heart Transplanted Child with Dilated Cardiomyopathy

Published:2020-06-01 Issue:2 Volume:6 Page:43-47
ISSN:2457-5518
Container-title:Journal Of Cardiovascular Emergencies
language:en
Short-container-title:

Author:

Muntean Iolanda¹,Barmou Asmaa Carla²,Sin Anca Ileana³,Suciu Horatiu⁴,Togănel Rodica¹

Affiliation:

1. Clinic of Pediatric Cardiology, Emergency Institute of Cardiovascular Diseases and Transplantation , “George Emil Palade” University of Medicine, Pharmacy, Science and Technology , Târgu Mureș , Romania

2. Clinic of Pediatric Cardiology, Emergency Institute of Cardiovascular Diseases and Transplantation , Târgu Mureș , Romania

3. Department of Cell and Molecular Biology , “George Emil Palade” University of Medicine, Pharmacy, Science and Technology , Târgu Mureș , Romania

4. Clinic of Cardiovascular Surgery, Emergency Institute of Cardiovascular Diseases and Transplantation , “George Emil Palade” University of Medicine, Pharmacy, Science and Technology , Târgu Mureș , Romania

Abstract

Abstract Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy in children. Heart transplantation is considered standard therapy in dilated cardiomyopathy with end-stage heart failure. We present a case of a 15-year-old patient diagnosed with DCM in the neonatal period, who underwent heart transplantation for end-stage heart failure. Despite the use of induction therapy, the endomyocardial biopsy performed at two weeks post-transplant revealed mixed moderate cellular (2R) and humoral (pAMR2) allograft rejection. Aggressive rejection treatment was initiated with good outcome. Besides endomyocardial biopsy, advanced echocardiography can also be a valuable noninvasive tool for rejection assessment.

Publisher

Walter de Gruyter GmbH

Subject

Automotive Engineering

Link

https://www.sciendo.com/pdf/10.2478/jce-2020-0007

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