Various clinical presentations of uveitis associated with durvalumab treatment

Author:

Vrabic Nika1,Fakin Ana1,Mekjavic Polona Jaki123,Janzic Urska4,Vrankar Martina5,Valentincic Natasa Vidovic12

Affiliation:

1. University Eye Clinic, University Clinical Centre Ljubljana , Ljubljana Slovenia

2. Faculty of Medicine, University of Ljubljana , Ljubljana Slovenia

3. Jožef Stefan Institute , Ljubljana , Slovenia

4. University Clinic of Pulmonary and Allergic Diseases Golnik , Ljubljana , Slovenia

5. Institute of Oncology Ljubljana , Ljubljana , Slovenia

Abstract

Abstract Background Immune checkpoint inhibitors (ICI) are becoming increasingly common in treating several cancer types. Durvalumab is a human IgG1 monoclonal antibody that blocks PD-L1 binding to PD-1 and CD80 and has recently been approved for the treatment of extensive-stage small-cell lung cancer (ES-SCLC) and locally advanced unresectable (NSCLC). The present review aimed to analyse immune-mediated uveitis, secondary to durvalumab treatment, through a review of the literature and a presentation of two clinical cases. Patients and methods A literature review using PubMed search was conducted to identify cases of uveitis secondary to durvalumab and cases of uveitis with optic disc oedema secondary to ICI use that were reported prior to November 14, 2021. Additionally, we report two cases of uveitis consequent on durvalumab treatment. Results Five cases of uveitis secondary to durvalumab use were identified in the literature. Anterior, posterior uveitis and vasculitis were reported. Additionally, we present a case of bilateral intermediate uveitis with bilateral optic disc oedema and a case of bilateral posterior uveitis. Our further search revealed 12 cases of uveitis with optic disc oedema secondary to ICI use, with the majority of cases reported secondary to PD-1 inhibitors. Conclusions Rarely reported, uveitis secondary to durvalumab can present various clinical pictures and requires a thorough diagnostic workup. Once the diagnosis is established, treatment, commonly with a local or systemic corticosteroid, should be adapted to the severity of the inflammation.

Publisher

Walter de Gruyter GmbH

Subject

Radiology, Nuclear Medicine and imaging,Oncology

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