Environmental Effect of Potential Radiopharmaceuticals Residuals

Abstract

Abstract Driven by the current development of quantitative structure-properties relationship (QSPR) methods in the environmental science, we proposed an approach based on chemometric tools for selection of appropriate physicochemical parameters of radiopharmaceuticals residuals for predicting of partitioning, hazards and biodegradation of such compounds into the environment or into wastewater treatment plant. The present scheme was successfully applied for prediction of missing values for 24 different physicochemical and assessment response of the environmental fate descriptors for 11 tetrazine derivatives and 12 cyclooctene derivatives. The multivariate statistics was also proved to be useful in the evaluation of the obtained modelling results for identification of the ecological effect of radiopharmaceuticals residuals. The presented approach can be one of the first steps and support tools in the assessment of chemicals in terms of their environmental impact. The problem studies are significant since it allows a special point of view to the underestimated radiopharmaceutical pollutants.