Aminoglycosides and Kidney Function

Abstract

Aminoglycosides and Kidney FunctionThe aminoglycosides are bactericide antibiotics with predominant effecting on the Gramm-negative bacteries, then staphylococci and mycobacteria with a small therapeutic range and with expressive ototoxic, nephrotoxic and with rare neurotoxic side effects. In this work the value of creatinine are investigated in serum of patients who are hospitalized in Internal department of the Health Center in Kosovska Mitrovica, before, in the course of and after therapy with the aminoglycosides antibiotics were given in different doses. The creatinine was determined by kinetic method (Jaffe). The significant increasing of creatinine values in serum was recorded with the groups of patients who have got gentamicine 2x120 mg i.m., gentamicine 2x120 mg in combination with furosemide, the gentamicine 2x120 mg with the patients with diabetes mellitus, gentamicine 2x120 mg in the course of 14 days until with the groups who have been getting gentamicine 1x120 mg, gentamicine 2x80 mg and amikacine 2x500 mg were not recorded the significant increased values of creatinine. The determination of creatinine for the sake of the following degree damage of kidney function in the course therapy of the aminoglycosides was very important.