Synthesis, structural and conformational study of selected N-substituted phthalimides-Reference-Cited by-同舟云学术

Synthesis, structural and conformational study of selected N-substituted phthalimides

Published:2005-12-01 Issue:4 Volume:3 Page:683-704
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Iriepa Isabel¹,Javier Villasante F.¹,Gálvez Enrique¹,Herrera Antonio²,Sánchez Angel²,Cano Felix³

Affiliation:

1. 1Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain

2. 2Universidad Complutense de Madrid, 28006, Madrid, Spain

3. 3Instituto de Química Fisica Rocasolano, (CSIC), 28006, Madrid, Spain

Abstract

AbstractThis paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/BF02475197.pdf

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