Expression of metalloproteinase 2 (MMP-2) and metalloproteinase 9 (MMP-9) in THP-1 macrophages cultured with three-dimensional titanium mini-plate systems used for surgical treatment of condylar fractures

Abstract

Osteosynthesis with the use of three-dimensional (3D) titanium mini-plate systems in the treatment of condylar fractures is a technique commonly used by maxillofacial surgeons. It is increasingly often mentioned in the literature, especially in the context of bone regeneration. The break in tissue continuity associated with this technique causes activation of pro-inflammatory responses mediated by matrix metalloproteinases MMP-2 and MMP-9, enzymes which are also involved in the subsequent bone remodelling. This study showed that the use of 3D titanium mini-plates did not alter the expression of these enzymes in THP-1 macrophages.