Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Author:

Agarwal Ashok12ORCID,Parekh Neel2ORCID,Panner Selvam Manesh Kumar12ORCID,Henkel Ralf13ORCID,Shah Rupin4ORCID,Homa Sheryl T.5ORCID,Ramasamy Ranjith6ORCID,Ko Edmund7ORCID,Tremellen Kelton8ORCID,Esteves Sandro910ORCID,Majzoub Ahmad111ORCID,Alvarez Juan G.12ORCID,Gardner David K.13ORCID,Jayasena Channa N.1415ORCID,Ramsay Jonathan W.15ORCID,Cho Chak-Lam16ORCID,Saleh Ramadan17ORCID,Sakkas Denny18ORCID,Hotaling James M.19,Lundy Scott D.2ORCID,Vij Sarah2ORCID,Marmar Joel20ORCID,Gosalvez Jaime21ORCID,Sabanegh Edmund2ORCID,Park Hyun Jun2223ORCID,Zini Armand24ORCID,Kavoussi Parviz25ORCID,Micic Sava26ORCID,Smith Ryan27ORCID,Busetto Gian Maria28ORCID,Bakırcıoğlu Mustafa Emre29ORCID,Haidl Gerhard30ORCID,Balercia Giancarlo31ORCID,Puchalt Nicolás Garrido32ORCID,Ben-Khalifa Moncef33ORCID,Tadros Nicholas34ORCID,Kirkman-Browne Jackson3536ORCID,Moskovtsev Sergey37ORCID,Huang Xuefeng38ORCID,Borges Edson39ORCID,Franken Daniel40ORCID,Bar-Chama Natan41ORCID,Morimoto Yoshiharu42ORCID,Tomita Kazuhisa42ORCID,Srini Vasan Satya43ORCID,Ombelet Willem4445ORCID,Baldi Elisabetta46ORCID,Muratori Monica47ORCID,Yumura Yasushi48ORCID,La Vignera Sandro49ORCID,Kosgi Raghavender50ORCID,Martinez Marlon P.51ORCID,Evenson Donald P.52ORCID,Zylbersztejn Daniel Suslik53ORCID,Roque Matheus54ORCID,Cocuzza Marcello55ORCID,Vieira Marcelo5657ORCID,Ben-Meir Assaf58ORCID,Orvieto Raoul5960ORCID,Levitas Eliahu61ORCID,Wiser Amir6263ORCID,Arafa Mohamed64ORCID,Malhotra Vineet65ORCID,Parekattil Sijo Joseph6667ORCID,Elbardisi Haitham64ORCID,Carvalho Luiz6869ORCID,Dada Rima70ORCID,Sifer Christophe71ORCID,Talwar Pankaj72ORCID,Gudeloglu Ahmet73ORCID,Mahmoud Ahmed M.A.74ORCID,Terras Khaled75ORCID,Yazbeck Chadi76ORCID,Nebojsa Bojanic77ORCID,Durairajanayagam Damayanthi78ORCID,Mounir Ajina79,Kahn Linda G.80ORCID,Baskaran Saradha1ORCID,Pai Rishma Dhillon81ORCID,Paoli Donatella82ORCID,Leisegang Kristian83ORCID,Moein Mohamed-Reza84ORCID,Malik Sonia85ORCID,Yaman Onder86ORCID,Samanta Luna87ORCID,Bayane Fouad88ORCID,Jindal Sunil K.89ORCID,Kendirci Muammer90ORCID,Altay Baris91ORCID,Perovic Dragoljub92ORCID,Harlev Avi93ORCID

Affiliation:

1. American Center for Reproductive Medicine, Cleveland Clinic, OH, USA.

2. Department of Urology, Cleveland Clinic, Cleveland, OH, USA.

3. Department of Medical Bioscience, University of the Western Cape, Cape Town, South Africa.

4. Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India.

5. School of Biosciences, University of Kent, Canterbury, UK.

6. Department of Urology, University of Miami, Miami, FL, USA.

7. Department of Urology, Loma Linda University Health, Loma Linda, CA, USA.

8. Department of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, Australia.

9. Division of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, Brazil.

10. Faculty of Health, Aarhus University, Aarhus, Denmark.

11. Department of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha, Qatar.

12. Centro Androgen, La Coruña, Spain and Harvard Medical School, Boston, MA, USA.

13. School of BioSciences, University of Melbourne, Parkville, Australia.

14. Section of Investigative Medicine, Imperial College London, UK.

15. Department of Andrology, Hammersmith Hospital, London, UK.

16. Department of Surgery, Union Hospital, Shatin, Hong Kong.

17. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.

18. Boston IVF, Waltham, MA, USA.

19. Department of Urology, University of Utah, Salt Lake City, UT, USA.

20. Cooper University Hospital, Camden, NJ, USA.

21. Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain.

22. Department of Urology, Pusan National University School of Medicine, Busan, Korea.

23. Medical Research Institute of Pusan National University Hospital, Busan, Korea.

24. Department of Surgery, McGill University, Montreal, QC, Canada.

25. Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.

26. Uromedica Polyclinic, Kneza Milosa, Belgrade, Serbia.

27. Department of Urology, University of Virginia, Charlottesville, VA, USA.

28. Sapienza University of Rome, Rome, Italy.

29. Istanbul Florence Nightingale Hospital, Istanbul, Turkey.

30. Department of Dermatology, University Hospital Bonn, Bonn, Germany.

31. Division of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Umberto I Hospital, Ancona, Italy.

32. IVI Foundation Edificio Biopolo - Instituto de Investigación Sanitaria la Fe, Valencia, Spain.

33. University Hospital, School of Médicine and PERITOX Laboratory, Amiens, France.

34. Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

35. Centre for Human Reproductive Science, IMSR, College of Medical & Dental Sciences, The University of Birmingham Edgbaston, UK.

36. The Birmingham Women's Fertility Centre, Birmingham Women's and Children's NHS Foundation Trust, Mindelsohn Drive, Edgbaston, UK.

37. Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.

38. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

39. Fertility Medical Group, São Paulo, Brazil.

40. Department of Obstetrics & Gynecology, Andrology Unit Faculties of Health Sciences, Tygerberg Hospital, Tygerberg, South Africa.

41. Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

42. IVF Japan Group, Horac Grand Front Osaka Clinic, Osaka, Japan.

43. Manipal Fertility, Bangalore, India.

44. Genk Institute for Fertility Technology, Genk, Belgium.

45. Hasselt University, Biomedical Research Institute, Diepenbeek, Belgium.

46. Department of Experimental and Clinical Medicine, Center of Excellence DeNothe, University of Florence, Italy.

47. Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Unit of Sexual Medicine and Andrology, Center of Excellence DeNothe, University of Florence, Florence, Italy.

48. Department of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan.

49. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

50. Androbest Andrology & Urology Center, Hyderabad, India.

51. Section of Urology, University of Santo Tomas Hospital, Manila, Philippines.

52. SCSA Diagnostics, Brookings, SD, USA.

53. Fleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil.

54. Origen, Center for Reproductive Medicine, Rio de Janeiro, Brazil.

55. Department of Urology, University of São Paulo (USP), Brazil.

56. Division of Urology, Infertility Center ALFA, São Paulo, Brazil.

57. Head of Male Infertility Division, Andrology Department, Brazilian Society of Urology, Rio de Janeiro, Brazil.

58. Fertility and IVF Unit, Department of Obstetrics and Gynecology, Hebrew-University Hadassah Medical Center, Jerusalem, Israel.

59. Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.

60. Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

61. Soroka University Medical Center, Ben-Gurion University of the Negev Beer-Sheva, Beersheba, Israel.

62. IVF Unit, Meir Medical Center, Kfar Sava, Israel.

63. Sackler Medicine School, Tel Aviv University, Tel Aviv, Israel.

64. Department of Urology, Hamad Medical Corporation, Doha, Qatar.

65. Department of Andrology and Urology, Diyos Hospital, New Delhi, India.

66. PUR Clinic, South Lake Hospital, Clermont, FL, USA.

67. University of Central Florida, Orlando, FL, USA.

68. Baby Center, Institute for Reproductive Medicine, São Paulo, Brazil.

69. College Institute of Clinical Research and Teaching Development, São Paulo, Brazil.

70. Lab for Molecular Reproduction and Genetics, Anatomy, All India Institute of Medical Sciences, New Delhi, India.

71. Department of Reproductive Biology, Hôpitaux Universitaires Paris Seine Saint-Denis, Bondy, France.

72. Department of Reproductive Medicine and Embryology, Manipal Hospital, New Delhi, India.

73. Department of Urology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

74. Department of Endocrinology/ Andrology, University Hospital Ghent, Ghent, Belgium.

75. Department of Reproductive Medicine, Hannibal International Clinic, Tunis, Tunisia.

76. Department of Obstetrics, Gynecology and Reproductive Medicine, Pierre Cherest and Hartman Clinics, Paris, France.

77. Clinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

78. Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Selangor, Malaysia.

79. Department of Embryology, Faculty of Medicine, University of Sousse, Sousse, Tunisia.

80. Department of Pediatrics, New York University School of Medicine, New York, NY, USA.

81. Department of Obstetrics and Gynaecology, Lilavati Hospital and Research Centre, Mumbai, India.

82. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

83. School of Natural Medicine, University of the Western Cape, Cape Town, South Africa.

84. Department of Andrology, Shahid Sadoughi Medical University, Yazd, Iran.

85. Southend Fertility & IVF, Delhi, India.

86. Department of Urology, School of Medicine, University of Ankara, Ankara, Turkey.

87. Redox Biology Laboratory, Department of Zoology and Center of Excellence in Environment and Public Health, Ravenshaw University, Cutrack, India.

88. Marrakech Fertility Institute, Marrakech, Morocco.

89. Jindal Hospital, Meerut, India.

90. Department of Urology, Istinye University Faculty of Medicine, Liv Hospital Ulus, Istanbul, Turkey.

91. Department of Urology, Ege University School of Medicine, İzmir, Turkey.

92. Center of Urology, CODRA Hospital, Podgorica, Montenegro.

93. Fertility and IVF Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

Funder

American Center for Reproductive Medicine

Publisher

Korean Society for Sexual Medicine and Andrology

Subject

Pharmacology (medical),Urology,Psychiatry and Mental health,Public Health, Environmental and Occupational Health,Health Policy,Aging,Reproductive Medicine

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