Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems

Author:

Boyko A. I.,Artiukhov A. V.,Kaehne T.,di Salvo M. L.,Bonaccorsi di Patti M. C.,Contestabile R.,Tramonti A.,Bunik V. I.

Publisher

Pleiades Publishing Ltd

Subject

Biochemistry,General Medicine

Reference31 articles.

1. Bunik, V. I., and Degtyarev, D. (2008) Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins, Proteins, 71, 874-890, doi: https://doi.org/10.1002/prot.21766.

2. Tsepkova, P. M., Artiukhov, A. V., Boyko, A. I., Aleshin, V. A., Mkrtchyan, G. V., Zvyagintseva, M. A., Ryabov, S. I., Ksenofontov, A. L., Baratova, L. A., Graf, A. V., and Bunik, V. I. (2017) Thiamine induces long-term changes in amino acid profiles and activities of 2-oxoglutarate and 2-oxoadipate dehydrogenases in rat brain, Biochemistry (Moscow), 82, 723-736, doi: https://doi.org/10.1134/S0006297917060098.

3. Artiukhov, A. V., Grabarska, A., Gumbarewicz, E., Aleshin, V. A., Kahne, T., Obata, T., Kazantsev, A. V., Lukashev, N. V., Stepulak, A., Fernie, A. R., and Bunik, V. I. (2020) Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues, Sci. Rep., 10, 1886, doi: https://doi.org/10.1038/s41598-020-58701-4.

4. Nemeria, N. S., Gerfen, G., Yang, L., Zhang, X., and Jordan, F. (2018) Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the l-lysine, l-hydroxylysine and l-tryptophan degradation pathways from studies in vitro, Biochim. Biophys. Acta Bioenerg., 1859, 932-939, doi: https://doi.org/10.1016/j.bbabio.2018.05.001.

5. Nemeria, N. S., Gerfen, G., Nareddy, P. R., Yang, L., Zhang, X., Szostak, M., and Jordan, F. (2018) The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species, Free Radic. Biol. Med., 115, 136-145, doi: https://doi.org/10.1016/j.freeradbiomed.2017.11.018.

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