Modification of Sesquiterpene Lactones—Dehydrocostus Lactone and Alantolactone—by Click Chemistry Method. Cytotoxic Activity of the Obtained Conjugates
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Published:2022-06
Issue:6
Volume:92
Page:960-968
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ISSN:1070-3632
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Container-title:Russian Journal of General Chemistry
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language:en
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Short-container-title:Russ J Gen Chem
Author:
Artyushin O. I.ORCID, Sharova E. V.ORCID, Nikolaeva N. S.ORCID, Aleksandrova Yu. R.ORCID, Semakov A. V.ORCID, Neganova M. E.ORCID, Brel V. K.ORCID
Abstract
Abstract
A method for modifying sesquiterpene lactones using the click chemistry methodology has been developed. A series of conjugates of alantolactone and dehydrocostus lactone with alkoxy substituted benzylazides was obtained and their cytotoxic profile with respect to tumor cells of the A549, SH-SY5Y, Hep-2 and HeLa lines was evaluated. It has been shown that derivatives containing dehydrocostus lactone motif in their structure exhibit the highest cytotoxic activity.
Publisher
Pleiades Publishing Ltd
Subject
General Chemistry
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