Synthesis and Prediction of Antitumor Activity of New Fused Pyrano[3,4-c]pyridines and Pyrano[4′,3′:4,5]pyrido[2,3-d]pyrimidines

Abstract

Abstract One-pot methods were developed for the preparation of 6-amino-3-isopropyl-7-aryl substituted-8-thioxo(oxo)pyrano[3,4-c]pyridines derivatives. The latter served as starting materials for the synthesis of a new pyrano[4′,3′:4,5]pyrido[2,3-d]pyrimidine heterosystems. The proposed mechanisms of one-pot reactions were presented. Antitumor activity of new synthesized compounds was predicted by in silico methods.