Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry
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Published:2022-10
Issue:10
Volume:77
Page:1307-1314
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ISSN:1061-9348
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Container-title:Journal of Analytical Chemistry
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language:en
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Short-container-title:J Anal Chem
Author:
Kravets K. Yu.,Timakova S. I.,Grechnikov A. A.,Borodkov A. S.,Laptinskaya P. K.,Kuzmin V. S.,Simanovsky Ya. O.
Abstract
Abstract
We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times.
Publisher
Pleiades Publishing Ltd
Subject
Analytical Chemistry
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