Abstract
Abstract
Neuroendocrine control mediated by glucocorticoids is important
for maintaining the normal functioning of the brain and the balance
between the excitation and inhibition systems. Glucocorticoids regulate
the state of the brain glutamatergic system both directly, through receptors
on glutamatergic synapses, and indirectly. The dysfunction of the
hypothalamic–pituitary–adrenal (HPA) axis and its inability to optimally
regulate glutamatergic synaptic plasticity leads to the development
of neuropsychiatric diseases, while hyperglutamatergic conditions
can play a key role in their pathogenesis. Impaired glucocorticoid
control of glutamatergic processes underlies cognitive and emotional
disorders, epilepsy and a number of other cerebral pathologies,
being a common mechanism for the development of many brain diseases
and their comorbidities. In this regard, the study of the mechanisms
of interaction between the HPA axis and brain glutamatergic system
is of priority translational significance.
Subject
Physiology,Biochemistry,Ecology, Evolution, Behavior and Systematics
Cited by
2 articles.
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