Protective and Antioxidant Effects of Insulin on Rat Brain Cortical Neurons in an in vitro Model of Oxygen and Glucose Deprivation
Author:
Publisher
Pleiades Publishing Ltd
Subject
Physiology,Biochemistry,Ecology, Evolution, Behavior and Systematics
Link
https://link.springer.com/content/pdf/10.1134/S0022093023010027.pdf
Reference30 articles.
1. Chen Y, Guo Z, Mao YF, Zheng T, Zhang B (2018) Intranasal insulin ameliorates cerebral hypometabolism, neuronal loss, and astrogliosis in streptosotocin-induced Alzheimer’s rat model. Neurotox Res 33: 716–724. https://doi.org/10.1007/s12640-017-9809-7
2. Song Y, Ding W, Bei Y, Xiao Y, Tong HD, Wang LB, Ai LY (2018) Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes. Biomed Pharmacother 104: 474–484. https://doi.org/10.1016/j.biopha.2018.04.097
3. Fine JM, Stroebel BM, Faltesek KA, Terai K, Haase L, Knutzen K.E, Kosyakovsky J, Bowe TJ, Fuller AK, Frey WH, Hanson LR (2020) Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson’s Disease. Neurosci Lett 714: 134567. https://doi.org/10.1016/j.neulet.2019.134567
4. Milstein JL, Ferris HA (2021) The brain as an insulin-sensitive metabolic organ. Mol Metab 52:101234. https://doi.org/10.1016/j.molmet.2021.101234
5. Claxton A, Baker LD, Hanson AJ, Trittschuh EH, Collerton B, Morgan A, Callaghan M, Arbuckle M, Behl C, Craft S (2015) Long-acting insulin Detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer’s disease dementia. J Alzheimers Dis 44: 897–906. https://doi.org/10.3233/JAD-141791
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