The Role of DNA Methylation in Zebrafish Models of CNS Diseases
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Published:2024-05
Issue:3
Volume:60
Page:973-987
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ISSN:0022-0930
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Container-title:Journal of Evolutionary Biochemistry and Physiology
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language:en
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Short-container-title:J Evol Biochem Phys
Author:
Yushko L. V.,Shevlyakov A. D.,Romazeva M. A.,Apukhtin K. V.,Volgin A. D.,Abramov D. A.,Kotova M. M.,Kalueff A. V.
Abstract
Abstract
DNA methylation plays an important role in the regulation
of gene expression. Its deficits in the brain cause various neurological
diseases, including autism, schizophrenia and mood disorders. The
zebrafish (Danio rerio) is
a promising model organism in biomedicine. Given its high genetic
and physiological homology with humans, studying genome methylation
deficits in zebrafish can help elucidate the molecular processes
underlying the etiology and pathogenesis of various neurological
diseases, as well as develop novel therapies. Here, we discuss the
mechanisms of DNA methylation in the brain and the diseases associated
with its dysregulation in humans, as well as their genetic and pharmacological
models in zebrafish. We also evaluate the limitations of zebrafish
models and possible directions for further research in this field.
Mounting evidence summarized here supports zebrafish as an effective
model for elucidating the molecular mechanisms of brain pathologies
associated with compromised DNA methylation.
Publisher
Pleiades Publishing Ltd
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