Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress-Reference-Cited by-同舟云学术

Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress

Published:2024-07-13 Issue:1 Volume:517 Page:264-268
ISSN:1607-6729
Container-title:Doklady Biochemistry and Biophysics
language:en
Short-container-title:Dokl Biochem Biophys

Author:

Kolodeeva O. E.^ORCID,Kolodeeva O. E.^ORCID,Averinskaya D. A.^ORCID,Makarova Yu. A.^ORCID

Abstract

Abstract Translation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line was investigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysis revealed that viscumin induces the ER stress activated by the PERK sensor.

Publisher

Pleiades Publishing Ltd

Link

https://link.springer.com/content/pdf/10.1134/S1607672924600301.pdf

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