The Human TREX-2 Complex Interacts with Subunits of the ORC Complex
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Published:2023-12
Issue:1
Volume:513
Page:346-349
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ISSN:1607-6729
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Container-title:Doklady Biochemistry and Biophysics
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language:en
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Short-container-title:Dokl Biochem Biophys
Author:
Kurshakova M. M.,Georgieva S. G.,Kopytova D. V.
Abstract
Abstract
The TREX-2 protein complex is the key complex involved in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a joint protein complex of TREX-2 with ORC was isolated in D. melanogaster. It was shown that the interaction of TREX-2 with ORC is necessary for efficient mRNA export from the nucleus to the cytoplasm. In this work, we showed that the TREX-2-ORC joint complex is also formed in human cells.
Publisher
Pleiades Publishing Ltd
Subject
General Chemistry,Biochemistry,General Medicine,Biophysics
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