Removal of the Translocation Domain and the Furin Cleavage Site Decreases the Relative Hepatotoxicity of the Targeted Antitumor Toxins
Author:
Publisher
Pleiades Publishing Ltd
Subject
General Chemistry,Biochemistry,General Medicine,Biophysics
Link
http://link.springer.com/content/pdf/10.1134/S1607672919060048.pdf
Reference9 articles.
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2. Bokori-Brown, M., Metz, J., Petrov, P.G., et al., Interactions between pseudomonas immunotoxins and the plasma membrane: implications for CAT-8015 immunotoxin therapy, Front. Oncol., 2018, vol. 8, p. 553. https://doi.org/10.3389/fonc.2018.00553
3. Weldon, J.E., Xiang, L., Chertov, O., et al., A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity, Blood, 2009, vol. 113, no. 16, pp. 3792–3800. https://doi.org/10.1182/blood-2008-08-173195
4. Sokolova, E., Proshkina, G., Kutova, O., et al., Recombinant targeted toxin based on HER2-specific DARPin possesses a strong selective cytotoxic effect in vitro and a potent antitumor activity in vivo, J. Control. Release, 2016, vol. 233, pp. 48–56. https://doi.org/10.1016/j.jconrel.2016.05.020
5. Sokolova, E., Shilova, O.N., Kiseleva, D.V., et al., HER2-Specific Targeted Toxin DARPin-LoPE: immunogenicity and antitumor effect on intraperitoneal ovarian cancer xenograft model, Int. J. Mol. Sci., 2019, vol. 20, no. 10, p. 2399. https://doi.org/10.3390/ijms20102399
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